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the pharmacokinetic profiles of indinavir at this dose were not comparable to profiles previously observed in adults receiving the recommended dose see clinical pharmacology, pediatric .

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copanlisib is a cyp3a substrate; indinavir is a strong cyp3a inhibitor.

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the ic 95 95 inhibitory concentration of indinavir in these test systems was in the range of 25 to 100 nm.

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during the initial phase of hiv treatment, patients whose immune system responds to indinavir therapy may develop an inflammatory response to indolent or residual opportunistic infections such as progressive multifocal leukoencephalopathy pml , mycobacterium avium complex mac , cytomegalovirus cmv , pneumocystis carinii pneumonia pcp , or tuberculosis tb , which may necessitate further evaluation and treatment.

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Although it is not known whether indinavir is excreted in human milk, there exists the potential for adverse effects from indinavir in nursing infants.

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